More than 250,000 Syrians have lost their lives in four-and-a-half years of armed conflict, which began with anti-government protests before escalating into a full-scale civil war. More than 11 million others have been forced from their homes as forces loyal to President Bashar al-Assad and those opposed to his rule battle each other – as well as jihadist militants from Islamic State.

Pro-democracy protests erupted in March 2011 in the southern city of Deraa after the arrest and torture of some teenagers who painted revolutionary slogans on a school wall. After security forcesopened fire on demonstrators, killing several, more took to the streets. The unrest triggered nationwide protests demanding President Assad’s resignation. The government’s use of force to crush the dissent merely hardened the protesters’ resolve. By July 2011,hundreds of thousands were taking to the streets across the country.

Violence escalated and the country descended into civil war as rebel brigades were formed to battle government forces for control of cities, towns and the countryside. Fighting reached the capital Damascus and second city of Aleppo in 2012. By June 2013, the UN said 90,000 people had been killed in the conflict. However, by August 2014 that figure had more than doubled to 191,000 – and continued to climb to 250,000 by August 2015, according to activists and the UN.A UN commission of inquiry, investigating alleged human rights violations since March 2011, has evidence that those on both sides of the conflict have committed war crimes – including murder, torture, rape and enforced disappearances. Government and rebel forces have also been accused by investigators of using civilian suffering – such as blocking access to food, water and health services – as a method of war.

In February 2014, a UN Security Council resolution demanded all parties end the “indiscriminate employment of weapons in populated areas”. Since then, activists say, more than 6,000 civilians have been killed by barrel bombs dropped by government aircraft on rebel-held areas. The UN says in some instances, civilian gatherings have been deliberately targeted, constituting massacres.Hundreds of people were killed in August 2013 after rockets filled with the nerve agent sarin were fired at several agricultural districts around Damascus. Western powers, outraged by the attack, said it could only have been carried out by Syria’s government. The regime and its ally Russia blamed rebels.

Facing the prospect of US military intervention, President Assad agreed to the complete removal or destruction of Syria’s chemical weapons arsenal as part of a joint mission led by the UN and the Organisation for the Prohibition of Chemical Weapons (OPCW). The destruction of chemical agents and munitions was completed a year later.Despite the operation, the OPCW has since documented the use of toxic chemicals, such as chlorine and ammonia, by the government in attacks on rebel-held northern villages between April and July 2014 that resulted in the deaths of at least 13 people.Islamic State has also been accused of using homemade chemical weapons, possibly including the blistering agent sulphur mustard, against Kurdish forces and civilians in northern Syria.More than four million people have fled Syria since the start of the conflict, most of them women and children. It is one of the largest refugee exoduses in recent history. Neighbouring countries have borne the brunt of the refugee crisis, with Lebanon, Jordan and Turkey struggling to accommodate the flood of new arrivals. The exodus accelerated dramatically in 2013, as conditions in Syria deteriorated.

A further 7.6 million Syrians have been internally displaced within the country, bringing the total number forced to flee their homes to more than 11 million – half the country’s pre-crisis population. Overall, an estimated 12.2 million are in need of humanitarian assistance inside Syria, including 5.6 million children, the UN says.In December 2014, the UN launched an appeal for $8.4bn (£5.6bn) to provide help to 18 million Syrians, after only securing about half the funding it asked for in 2014. By a year later, it was less than half funded.The armed rebellion has evolved significantly since its inception. Secular moderates are now outnumbered by Islamists and jihadists, whose brutal tactics have caused widespread concern and triggered rebel infighting. Capitalising on the chaos in the region, Islamic State – the extremist group that grew out of al-Qaeda in Iraq – has taken control of huge swathes of territory across northern and eastern Syria, as well as neighbouring Iraq. Its many foreign fighters in Syria are now involved in a “war within a war”, battling rebels and jihadists from the al-Qaeda-affiliated Nusra Front, who object to their tactics, as well as Kurdish and government forces.

With neither side able to inflict a decisive defeat on the other, the international community long ago concluded that only a political solution could end the conflict in Syria. However, a number of attempts by the Arab League and the UN to broker ceasefires and start dialogue have failed.In January 2014, the US, Russia and UN convened a conference in Switzerland to implement the2012 Geneva Communique, an internationally backed agreement that called for the establishment of a transitional governing body in Syria formed on the basis of mutual consent.The talks, which became known as Geneva II, broke down in February after only two rounds. The then-UN special envoy Lakhdar Brahimi blamed the Syrian government’s refusal to discuss opposition demands and its insistence on a focus on fighting “terrorists” – a term Damascus uses to describe rebel groups.UN Secretary General Ban Ki-moon says the organisation’s long-term strategic objective remains apolitical solution based on the Geneva Communique. The UN special envoy Staffan de Mistura has also proposed establishing a series of “freeze zones”, where local ceasefires would be negotiated to allow aid deliveries in besieged areas. But his attempt to broker a truce in Aleppo in March 2015 was rejected by rebels in the city, who feared the government would use it to redeploy its forces elsewhere and that IS militants would simply ignore it.

What began as another Arab Spring uprising against an autocratic ruler has mushroomed into a brutal proxy war that has drawn in regional and world powers.Iran and Russia have propped up the Alawite-led government of President Assad and gradually increased their support.Tehran is believed to be spending billions of dollars a year to bolster Mr Assad, providing military advisers and subsidised weapons, as well as lines of credit and oil transfers. In September 2015, Russia launched an air campaign against Mr Assad’s opponents. Moscow said it was targeting only “all terrorists”, above all members of Islamic State, but many of the strikes hit Western-backed rebels and civilians.The Syrian government has also enjoyed the support of Lebanon’s Shia Islamist Hezbollah movement, whose fighters have provided important battlefield support since 2013.

The Sunni-dominated opposition has, meanwhile, attracted varying degrees of support from its main backers – Turkey, Saudi Arabia, Qatar and other Arab states along with the US, UK and France. However, the rise of hardline Islamist rebels and the arrival of jihadists from across the world have led to a marked cooling of Western backing.US-led coalition aircraft provide significant support to Kurdish militia fighters seeking to defend three autonomous enclaves in the country’s north from attacks by IS. But a programme to train and arm 5,000 Syrian rebels to take the fight to IS on the ground has suffered embarrassing setbacks.

Though it is unclear that what will happen next, one thing is for sure that this crises will have a long term effect on the European economy not to mention the threat of proxy war between Russia and USA is becoming more and more real everyday.