Born in New York City in 1952, Nisan moved in 1967 to St. Thomas, US Virgin Islands. He graduated from Colgate University, and received an MA in Biology from William and Mary. Nisan resided in Charlottesville, VA, Newtonville, MA, and Baltimore, MD before making aliyah in 2013. He has been married for 40 years, with three adult children and ten grandchildren. He lives in Efrat.